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Evidence is increasing that every addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This area of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err along the side of caution and permit the FDA do its job and demand some research be done so that the public is aware of the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their medications.

Researchers found that participants using this drug for any year, dropped a few pounds within four weeks and have kept the body weight off through the entire 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more effective and safer.

Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there are not any long term prescription slimming capsules that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise hypertension and heartrate, and really should not be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure levels, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.


New UCLA study on smokers with mental, drug, and alcohol problems