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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence based on a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you ought to err assisting caution and allow FDA do its job and demand some research be done so that the public understands the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on the medications.

Researchers discovered that participants investing in this drug for the year, dropped a few pounds within 4 weeks and have kept the weight off throughout the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them far better and safer.

Combo-pilling will be the newest fad or also the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that as of right now there are not any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure levels and heartrate, and really should not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.


Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside liver shortly after uptake from your intestines and contains no therapeutic effect. Buprenorphine will be the active substance; it really is absorbed under the tongue (and throughout the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who may have had gastric bypass, where the first section of the intestine is bypassed and the stomach contents empty right into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the place that the drug is taken up with the duodenum and transferred straight to the liver from the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be taken on by servings of the intestine that aren't served from the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.